Clinical background
Cervical cancer is theφ fourth most malignant tumor in w₩₽omen. According to data published by th↓ e National Cancer Center, in 2♥÷₽σ015, there were about 98®₩,900 new cases of cervical cancer and≤ about 30,500 deaths in China, which are serioוε₽usly threatening the health and lif ♥←±e of women in China. At present, ≠¶®studies have confirmed that persistent infecti£☆on of high-risk human papillomavirus (HPV) is a ↓✘necessary condition ₽>for cervical cancer to develop. 28 HPV g•∞≈βenotypes: including HPV hi✘λπ®gh-risk types: 16, 18, 31, 33, 35, 39, 45,π₹α 51, 52, 56, 58, 59, 68; HPV suspected high-r ¶isk types: 26, 53, 66, 7§♥δ₽3, 82; HPV low-risk type: 6, 11, 40,₹ • 42, 43, 44, 54, 61, 81, 83
Significance of genetic testing
1. It is suitable for genetε♠•ic diagnosis of clinical HPV in≠ fection, assisting the s •creening of condyloma acu¶✔₹↓minatum and cervical cance≤♣πr, and monitoring its treatment ₽←Ω∏effect, etc., which can p™σ∞φrovide a scientific basis for★<≠✘ the diagnosis of patients with HPV-related •diseases;
2. Cervical cancer is the©★ only clear cause and ca≈εn be early Cancer detection and prevention, ε₩early elimination. The International Canc₩∑ er Society believes tha↑ΩΩt persistent infection of high-risk HPV viruse→β≈s is the main cause of cervical cancer. →™The detection of HPV typinεg can be used to determine t©€ε>he risk of cervical cance≈€r and achieve individualized tumor pre>♣vention and treatment;
3. Different types of HPV infe↓ ₩ction cause cervical cancer Risk$♦'s are different, and typ↑®≈ing test can provide guidance for risk asse♥₩ssment and epidemiolo✔σgical investigation;
4. Guide the shunt treatment of cervical®&± cytology test results ASCUS and LSIL,♦♠↓± exclude suspicious lesions and lowΩ$λ€-grade lesions, improve diagnosis credib↓∑₩φility and reduce missed diagnosis Risk;
5. Can be used for follow-up treatment of cer'∑vical cancer lesions.
Product advantages
1. High-throughput, sensitive, specific ≥γ× and fast, can simultaneous↓∞Ω↓ly detect 28 kinds of HP¥®£®V genotypes
2. Fast detection, stable e ♠>©xperimental method, low cost, and the§₽ required equipment price is not hig✘↓h
3.28 kinds of HPV genotypes : Includes¶₽"∏ HPV high-risk types: 16, 18, €λ31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68; HPV♦≠ suspected high-risk types: 26, 53, 66, 73♣≠Ω, 82; HPV low-risk Type: 6,11,40,42,4✘≈↑3,44,54,61,81,83
4. Specificity above 98%, no cross reactionσ &δ between types
5. Accuracy above 98%
6. Repeatability above 98%
7. High sensitivity, detect the minimum co αpy number of HPV-DNA¥¶→ 104copies / mL
Application field
1. By detecting whether there is ₩ε∏↑a high-risk HPV infe≠βction, combined with cervical cyto∞↔logy screening for cervical cancer,$>¶α to better determine th↓× ÷e risk of cervical lesion$s
2. For atypical squamous cells an€®±d gland cells (AS-CUS / AGUS) and™γ× cervical Shunting and manageme→↓nt of people with low-gr&σ£ade intraepithelial lesion↓€s (LSIL)
3. Tracking and follow-up after treatment ¥•of cervical lesions 4.
Important basis for HPV epidemiological inve×stigation and vaccine ♣∞development
Product information
Test specimens : Cervical exfoliated cell samples, genitourinaryδβ tract secretions
Technical principle : PCR-reverse dot hybrid•₽♣♣ization
Packaging specifications : 25 tests / kit
Class : In vitro diagnostic r™'♠✘eagents
Applicable instruments : Gene amplification instrument, molec∑®λular hybridization instrument
