MTHFR and MTRR gene polymorphic site detection kits (PCR fluorescence dissolutio
MTHFR and MTRR gene polymorphic site detection kits (PCR fluorescence dissolution method)

MTHFR and MTRR gene polymorphic site d★∏etection kits (PCR fluorescence dissol≈±ution method)

Clinical background

  In the folic acid metabolism pat±"÷☆hway, single nucleotide 󧕱polymorphisms (SNPs) of methα$ylenetetrahydrofolate reductase (MTHF↕÷R) and methionine synthetase reducta¶↑™se (MTRR) can affect the activity of MTHF≥α¶♥R and MTRR synthase, and Affects the leve✘$l of serum folic acid or h‌∏​§omocysteine. It will cause hypofolat♦≈ βe and hyperhomocysteinemia, which will inc‌β£γrease the risk of birth defects, neural tube"∞ diseases and cardiovascular diseases in neδ♠←™wborns.
  The "China Cardio‌₹φvascular Disease 2015" report shows‌∞₽ that: China's cardiovascularΩ•§☆ disease accounts for the highest mortality rate ↓₩of residents in China, and the nu♥$✘mber of cardiovascular pati<£φents will continue to increas±©σe in the next ten yea¥☆₹λrs. At the same time, there are €≈< about 800-1.2 million new cases&δα of birth defects in China every year. Therefore ∞≠♦, folic acid gene testing is carriΩ≠♠ed out to personalize folic acid supplemeε∞ntation for people with folic acid mutatio©&↓ns, so as to fundamentally pr←<event the risks of birth defects, neural tubπΩ>e diseases and cardiovascula¥'→r diseases.


Inspection diagram

Figure 1: Methyltetrahydrolysis (MTHFR)gene C∞★677T(rs1801133) 
Figure 2: Methyl tetrahydrofol$÷©ilic acid reductase (MTHFR)≠±>∞MTHFRgene A1298C(rs1801131) 
Figure 3: Methylthion s↕™ ynthetic reductase (MTRR)MTRRgene A66G(rs1 ↓≥∏801394)

The Significance of Gene Testing
Early detection is caused by genetic f Ω✘actors, which can prov®π♥ide guidance for people who lack folic aci∞βd to achieve precise medication;£→
Provide the basis for the ¥♥ ✘onset of hyperhomocysteinemia patient≥ββ s;
Defining the family genetic history and providi✔×ng guidance for eugenics and personalized m↑∞♥edicine;
Gene mutations can be accurately detected.
Product advantages
Comprehensive:The first to detect three major mutations in the↓&±® Chinese population at the s£‍ ↔ame time, enabling a more ​ comprehensive assessment of the sub₩←•σject's folic acid util​↑∞γization capacity；
Accurate:Use a large number of clinical samples to ve↓φ♣rify, and the coincidence rate with sequen≤‌cing is 100%, to avoid wrong or missed✘∑☆↑ tests;
The operation is simple and fast: one tube detects three site$± s, which takes less time from the  ®β♥experiment to the results, stable performa∑∞Ω©nce, high repeatability, and the t&₩¥≈est results can be quickly≤λ and accurately interpreted, simple and ​•clear；
Genetic testing: Qualitative identifica£γtion of folic acid risk genes to achieve per♥♠←sonalized folic acid supplementation with rel>λiable results for life;

High sensitivity:&nbs>÷×p;The detection limit of the genomic DNA of t✘✔he examinee is 2ng / μL↕α>；


National 973 project, top international and d♠​αomestic experts devote them®​selves to creating


Application areas
Analysis of the causes≈÷¶  of high-like cystei‌ λγneemia 
Pregnant women: prevention of birth defe₽≈↑₩cts, spontaneous abortion, pregnancy hypertensi✘↓on, etc. 
Women with a bad pregnancy history≤π: prevention of adverse pregnancy recurrenc☆ e
Product information

Detection of specimens: Anticoagulant whole blood or ge₩♣ nomic DNA

Technical principle: PCR-fluorescent melting method

Packing size:24 tests / kit,48 tesλ∑εφts / kit

Category:In vitro diagnostic reagents

Suitable for instruments: Fluorescence quantitative PCR instr§≈ument

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